John (Zhanxiang) Wang, L.Ac., MD(China), Ph.D.

Wang1

Dr. Wang graduated from Beijing University of Chinese Medicine (BUCM) with his MD degree in 1989. He completed training in applying Chinese medicine and acupuncture to treat many patients with neurology, orthopedics and traumatology, cardiology, nephrology, pneumology, hematology, cancer, gastrointestinology, and gynecology diseases. He practiced as chief physician at the China Academy of Chinese Medicine Sciences (CACMS) for more than 10 years, where he also received a PhD degree in Chinese medicine and integrated medicine.

Dr. Wang is a National Certification Commission of Acupuncture and Oriental Medicine (NCCAOM) certified acupuncturist and herbalist with over 20 years of clinical experience (Zhanxiang Wang at NCCAOM website). He is dedicated to his patients and passionate about his practice. Dr. Wang has also conducted cancer, leukemia, immune system disorder, and diabetes research at Indiana University School of Medicine. He has received academic awards and grants from CACMS and National Institute of Health (NIH). He has also authored numerous books and publications of TCM and integrated medicine and has been invited to present at international conferences. Currently Dr. Wang is a professor at the National University of Health Sciences, where he teaches both oriental and western medicine.

Dr. Wang’s clinic is the board member of Acupuncture Corporation of America (ACA) in the Chicago area. With extensive integrated knowledge in medicine, Dr. Wang is able to provide the best possible care for the patients with a wide variety of health conditions.

Qualifications
Acupuncturist: certified by NCCAOM.
Herbologist: certified by NCCAOM.
Acupuncturist:  licensed by Illinois state.
M.D. in China

 

Curriculum Vitae:

Education & Training
1983 – 1989: M.D. Beijing University of Chinese Medicine. Beijing, China.
1996-2001: Ph.D. in integrated medicine. China Academy of Chinese Medicine Sciences. Beijing, China.
2001-2002: Post doctor training on cancer Pathology, Umea University, Sweden.

Work Experience:
1989 – 1994: Resident physician. Xi-Yuan Hospital, China Academy of Chinese Medicine Sciences, Beijing, China.
1995 – 2001: Attending physician (Doctor-in-Charge). Xi-Yuan Hospital, China Academy of Chinese Medicine Sciences. Beijing, China.

2002—2015: Researcher and Assistant Professor. Research on cancer/hematology pathology, herbal medicine/diabetes and immunology/asthma. Indiana University School of Medicine.
2008 – Present: Licensed Acupuncturist and Herbalist. Indiana and Illinois.
2014–Present: Professor & clinical instructor. National University of Health Sciences, IL.

 

Peer-reviewed publications:


Blood & Kidney related papers in Chinese medicine and Acupuncture:

  1. The pathology mechanism of Blood Deficiency in Women Constitution. School Reports of Gan Su Chinese Medicine College.10(4):8, 1993
  2. Clinical study on treatment of aplastic anemia mainly with Yishen (Tonify Kidney)-Shengxue (generating blood)  herbs. Journal of integration of Western and Chinese herbal Medicine1998.
  3. Clinical and experimental study on myelodysplastic Syndromes with Fuzheng (Tonifying Kidney) and bone marrow)-quxie(herbs). Chinese Journal of integration of Western and Chinese herbal Medicine, 1999.
  4. Effects of Yishen (Tonify Kidney)-Shengxue (generating blood) herbs on hematopoietic stem cells from mice aplastic anemia model. Chinese Journal of Basic Medicine in Chinese herbal Medicine ,1999.
  5. Clinical study on children aplastic anemia with Yishen (Tonify Kidney)-Shengxue (generating blood)Chinese herbs. Chinese J. of information of Chinese Herbal Medicine, 2001.
  6.  Experimental study on K562 cells and hematopioetic stem cells with Fuzheng(Tonifying Kidney and Blood)-Quxie herbs. Chinese J. of Basic Chinese Herbal Medicine,2001.
  7. Wang Z and Zhang H: How We Treat Frozen Shoulder (by acupuncture).  Meridians: The Journal of Acupuncture & Oriental Medicine 2014: Fall Vol. 1(1) p36.
  8. B Feng, Z. Wang and Y Kwon: Effects of Acupuncture in treatment of Hypertension. Journal of Acupuncture and Oriental Medicine: 2016 Winter Vol3(1):p19
  9. Wang, H Wei and H Tian: Evidence-based Acupuncture: Report on the First Congress of Evidence-based Acupuncture and Chinese Medicine Journal of Acupuncture and Oriental Medicine: 2016 Winter Vol3(1):p17-20.

 

Oncology and Leukemia related papers in Chinese medicine:

  1. Long-living cases of Chronic Myeloid leukemia treated by Chinese herb formula. Journal of Chinese Leukemia, 1998.
  2. Treatment of acute promyeloid leukemia with Chinese medicine Ai-Ling-1. Chinese Journal of integration of Western and Chinese Herbal Medicine, 1999.
  3. Long-living cases of acute leukemia treated by traditional Chinese herb Formula. Chinese Leukemia, 1999.
  4. Treatment of polycythemia vera with Traditional Chinese herb formula. Journal Of Modern Chinese herbal Medicine,1999.
  5. Apoptosis and tolemerase activity changes induced by arsenic trioxide. Chinese Journal of integration of Western and Chinese herbal Medicine,2000.
  6. Influence of antioxidants on apoptosis induced by arsenic trioxide. J. Chinese Leukemia, 2000.
  7. Clinical study on senior acute myeloid Leukemia with Chinese herbs and Western medicine. J. of Information of Chinese herbal Medicine, 2001.

Authorship of Books on Traditional Chinese Medicine

  1. Function and contradiction of common-used Traditional Chinese Herbs, 1993.
  2. Contemporary Hematology of Chinese Herbs and Western Medicine, 1997.
  3. Clinical Hematology of Integration of Chinese herbs and Western Medicine, 1998.
  4. Protection of Cancer Patients with Chinese Herbs and western medicine after chemotherapy, 2000.
  5. Acute Leukemia and integrative treatment, 2000.
  6. Integrative treatment of Chronic Leukemia and Myelodysplastic Syndromes, 2000.

Membership of Professional Organizations:

2005    Associate Member, American Society of Hematology

2006   Member, American Society of Hematology

2007   Member, American Society of Cell biology

2010-present   Member, Sigma Xi Scientific Research Society

2010-2015, member, The Indiana Association of Acupuncture & Oriental Medicine

2014-present, member TCMAAA

2016-, member, The Illinois Association of Acupuncture & Oriental Medicine

 

Cancer and Diabetes related papers:

  1. Expression and subcellular localization of individual p63 isoforms in normal tissue and neoplastic cells . Journal of Pathology, 2002.
  2. Survivin regulates the p53 tumor suppressor gene family. Oncogene. 2004.
  3. Disruption of the inhibitor of apoptosis protein Survivin sensitizes Bcr-abl-positive cells to STI571-induced apoptosis. Cancer Res. 2005.
  4. Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion. J Biol Chem. 2007.
  5. Filamentous actin regulates insulin exocytosis through direct interaction with Syntaxin 4. J Biol Chem. 2008.
  6.  Disruption of Survivin in K562 cells elevates telomerase activity and protects cells against apoptosis induced by the Bcr-abl kinase inhibitor STI571. Cancer Therapy. 2008.
  7. Mechanisms of biphasic insulin-granule exocytosis – roles of the cytoskeleton, small GTPases and SNARE proteins (peer reviewed commentary) . J Cell Sci. 2009.
  8. Differential phosphorylation of RhoGDI mediates the distinct cycling of Cdc42 and Rac1 to regulate second-phase insulin secretion. J Biol Chem. 2010.
  9. Cool-1/{beta}PIX Functions as a Guanine Nucleotide Exchange Factor (GEF) in the Cycling of Cdc42 to Regulate Insulin Secretion. Am J Physiol Endocrinol Metab. 2011.
  10. Inhibition or Ablation of p21-activated Kinase (PAK1) Disrupts Glucose Homeostatic Mechanisms in Vivo. J Biol Chem. 2011
  11. Gelsolin Associates with the N Terminus of Syntaxin 4 to Regulate Insulin Granule Exocytosis. Mol Endocrinol. 2012.
  12. Antidiabetic Effects of Ginseng in Humans and Rodents.  J. of Metabolic Syndrome. 2012.
  13. PAK1 limits the expression of the pro-apoptotic protein BAD in pancreatic islet β-cells. FEBS Bio Open ,2012.

 

Awards and Funding:

1993—1996: Principle Investigator. Young Investigator Fund award 93C043. Title: Clinical and experimental study on Myelodysplastic Syndromes with Chinese Herbs.  National Administration of Chinese Medicine of the People’s Republic of China.

1998—1999: Advanced Scientific Research Award in traditional Chinese medicine from China Academy of Chinese Medicine Sciences.

2003—2005: Academic awards from Walther Oncology Center (WOC). Indiana University School of Medicine.

2011—2013: Principle Investigator. CTSA career award CTSI-KL2 RR025760. Title: Delay diabetes development through dietary (including Ginseng) mediated Pak1 activation. NIH/NCRR- Indiana Clinical and Translational Sciences Institute– K12 Program.

2012: Added to reviewer database for Chinese Journal of Integrative Medicine.
2012: Nominated to serve on the Associate Scientific Advisory Board for Science’s sister journal, Science Translational Medicine by American Association for the Advancement of Science.

2016: Guest speaker in international conference in Beijing, China:  Annual Conference of Hematology Specialist Committee World Federation of Chinese Medicine Societies.

 

Invited presentation/Guest speaker events:

Invited presentations:

     2006: Islet Biology Journal Club, Indiana University School of Medicine—   Title: The Role of Rho Family GTPases in Insulin Exocytosis.

    2012: Center for Diabetes Research, Indiana University School of Medicine—Title:  Dual role of P21-activated Kinase-Pak1 in Pancreatic β-cells-Anti-Apoptotic Effects    of Dietary Supplements in Pancreatic Islet β-cells.

      2016, Guest speaker in international conference in Beijing, China:  Annual Conference of     Hematology Specialist Committee World Federation of Chinese Medicine Societies.

Other meeting presentations:

  1. Wang Z, Fukuda S and Pelus L. Regulation of the tumor suppressor gene p53 and by survivin contributes to its anti-apoptotic effects. Walther Cancer Institute Annually Retreat (Notre Indianapolis, IN). 08/2003. Oral presentation.
  2. Wang Z, Fukuda S and Pelus L. Regulation of the tumor suppressor gene p53 and the cyclin dependent kinase, Cdc2, by Survivin contributes to its anti-apoptotic effects. 45th Annual Meeting of American Society of Heamtology (San Diego, CA). 12/2003: Poster presentation.
  3. Wang Z, Fukuda S and Pelus L. Disruption of the inhibitor-of-apoptosis protein, survivin, sensitizes Bcr-Abl positive cells to STI571 (Gleevec)-Induced apoptosis. Walther Cancer Institute Annually Retreat (Notre Dame, IN). 08/2004: Oral presentation.
  4. Wang Z, Fukuda S and Pelus L. Disruption of the inhibitor-of-apoptosis protein, survivin, sensitizes Bcr-Abl positive cells to STI571-Induced apoptosis. 46th Annual Meeting of American Society of Hematology (Atlanta, GA). 12/2004: Poster presentation.
  5. Wang Z. The Role of Rho Family GTPases in Insulin Exocytosis. Islet Biology Journal Club, Indiana University School of Medicine (Indianapolis, IN). 05/2006: Oral presentation.
  6. Wang Z, Oh J and Thurmond D. Cdc42 is required in glucose induced insulin secretion and Rac1 activation in beta-cells. Annual Meeting of American Society of Cell Biology (San Diego, CA). 12/2006:Poster presentation.
  7. Wang Z. A potential role for the actin binding protein Filamin A in insulin secretion. Islet Biology Journal Club, Indiana University School of Medicine (Indianapolis, IN). 04/2007: Oral presentation.
  8. Wang Z and Thurmond D. Identification of RhoGDI as the Guanine Dissociation Inhibitor for the Cytosolic Pool of Cdc42 in Pancreatic Beta Cells. Keystone Symposia: Islet and Beta Cell Biology (Z3) (Snowbird, UT). 04/2008: Poster presentation.
  9. Wang Z, Oh E, Clapp DW, Chernoff J, Thurmond DC. The Cdc42-Pak1 signaling pathway controls second-phase insulin release in human islets: aberrant whole-body glucose homeostasis in Pak1-deficient mice. Midwest Islet Conference (Indianapolis, IN). 05/2010: Poster presentation.
  10. Kepner EM, Yoder SM, Kalwat MA, Wang Z, Thurmond DC.  Cool-1/βPix functions as a GEF protein in the cycling of Cdc42 to regulate insulin secretion.  Midwest Islet Club (Madison, WI). 05/2011: Poster presentation.
  11. Wang Z, DiMeglio L, Mather K and Thurmond D. Pak1 is a molecular target for the preservation of β-cell survival. Translational Science (Washington, DC). 04/2012: Poster presentation.
  12. Kalwat MA, Wang Z, Yoder SM, Thurmond DC. A novel p21-activated kinase (PAK1) signaling cascade couples glucose–induced amplification of insulin secretion to F-actin remodeling. Midwest Islet Club Conference. 05/2012: Poster presentation.
  13. Kalwat MA, Wang Z, Yoder SM, Thurmond DC. A novel p21-activated kinase (PAK1) signaling cascade couples glucose-induced amplification of insulin secretion to F-actin remodeling. American Diabetes Association 72ndScientific Sessions (Philadelphia, PA). 06/2012: Oral presentation.
  14. Wang Z, DiMeglio L, Mather K and Thurmond D. Pak1 is a molecular target for the preservation of β-cell. Indiana Clinical and translational Sciences Institute 4th Annual meeting (Indianapolis, IN). 08/2012: Poster presentation.
  15. Wang Z, DiMeglio L, Mather K and Thurmond D. A role for PAK1 mediated signaling in the prevention of beta-cell failure. Translational Science (Washington, DC). 04/2013: Poster presentation.
  16. B Feng, Z Wang and Y Kwon. Effects of Acupuncture in treatment of Hypertension. 1st Congress of Evidence-Base Acupuncture and Chinese Medicine, Oct3-4, 2015, Orlando, Florida
  17. The p21-Activated Kinase (PAK1) Is Required for Diet-Induced beta-Cell Mass Expansion and Survival the Annual Meeting Steering Committee for a poster presentation at ENDO 2016.